Area of research
Cancer Research · Molecular Biology
Research interest
Research interests include Cancer, Hypoxia, and Metabolism, Metabolism, Diabetes, and Cancer, Epigenetics and DNA Methylation, and Cancer, Lipids, and Metabolism.
l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression
High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients
Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice
Electron transport chain inhibition increases cellular dependence on purine transport and salvage
Metabolic inflexibility promotes mitochondrial health during liver regeneration
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
Compartmentalized metabolism supports midgestation mammalian development
In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma
SNAT7 regulates mTORC1 via macropinocytosis
Principles of reproducible metabolite profiling of enriched lymphocytes in tumors and ascites from human ovarian cancer
1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer
Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologies
Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer
Using arterial–venous analysis to characterize cancer metabolic consumption in patients
The transcription factors aryl hydrocarbon receptor and MYC cooperate in the regulation of cellular metabolism
Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation
γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
Automated Glycan Sequencing from Tandem Mass Spectra of N-Linked Glycopeptides