Area of research
Molecular Biology · Genetics
Research interest
Research interests include Epigenetics and DNA Methylation, Cancer-related gene regulation, Hemoglobinopathies and Related Disorders, and Sphingolipid Metabolism and Signaling.
Murine models of erythroid 5ALA synthesis disorders and their conditional synthetic lethal dependency on pyridoxine.
Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche
In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice
In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice.
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells
Enhancer dependence of cell-type–specific gene expression increases with developmental age
Transcriptome Dynamics of Hematopoietic Stem Cell Formation Revealed Using a Combinatorial Runx1 and Ly6a Reporter System
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis
An engineered CRISPR/Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells
PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer
A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations
Reduced <i>Erg</i> Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells
Chronic Myelogenous Leukemia– Initiating Cells Require Polycomb Group Protein EZH2
Strict in vivo specificity of the Bcl11a erythroid enhancer
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Hallmarks of pluripotency
Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence
Failure to replicate the STAP cell phenomenon
Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
RePEc: Research Papers in Economics 2015cited by 5position: middle
A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1
An Erythroid Enhancer of <i>BCL11A</i> Subject to Genetic Variation Determines Fetal Hemoglobin Level
Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity
<i>Lin28a</i> Regulates Germ Cell Pool Size and Fertility
Fine-Mapping and Genome Editing Reveal An Essential Erythroid Enhancer At The HbF-Associated BCL11A Locus
MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension