Area of research
Pulmonary and Respiratory Medicine · Physiology
Research interest
His laboratory research was focused on mechanisms of tissue remodeling and repair and clinical studies particularly related to chronic obstructive pulmonary disease and smoking cessation. He has received numerous awards including the Career Research Award of the Department of Internal Medicine, the Scientist Laureate Award of UNMC, and the Outstanding Research and Creativity Award of the University of Nebraska. He has served on the American Board of Internal Medicine, Pulmonary Committee, Board of Directors for the American Lung Association, the American Thoracic Society, the Alpha-1 Foundation and the COPD Foundation, on the initial committee that prepared the GOLD Guidelines and was an author of the COPD Foundation Guide for the Diagnosis and Management of COPD.
Correlates of 5-year decline in 6-min walk distance in the COPDGene cohort.
A Brief History of COPD: As Told by Some of Its Senior Scientists and Clinicians
Characteristics Associated with Lung Function Trajectories: An Analysis of the SPIROMICS Cohort.
Phenotypes and Trajectories of Tobacco-Exposed Persons with Preserved Spirometry: Insights from Lung Volumes
Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies
A novel method for determining ventilatory and gas exchange dynamics during exercise: the "chirp" waveform.
Targeting Type 2 Inflammation and Epithelial Alarmins in Chronic Obstructive Pulmonary Disease: A Biologics Outlook
Longitudinal Follow-Up of Participants With Tobacco Exposure and Preserved Spirometry
Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study
Increased chest CT derived bone and muscle measures capture markers of improved morbidity and mortality in COPD
Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study.
Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort
Characterization of Immunopathology and Small Airway Remodeling in Constrictive Bronchiolitis
Bronchodilator Responsiveness in Tobacco-Exposed People With or Without COPD
Reconsidering the Utility of Race-Specific Lung Function Prediction Equations
Objectively Measured Physical Activity in Patients with COPD: Recommendations from an International Task Force on Physical Activity
Relationship between Emphysema Progression at CT and Mortality in Ever-Smokers: Results from the COPDGene and ECLIPSE Cohorts.
Small airway determinants of airflow limitation in chronic obstructive pulmonary disease.
Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers
Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in COPD
Objectively Measured Physical Activity as a COPD Clinical Trial Outcome
Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort.
Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease
Blood Eosinophil Counts in Clinical Trials for Chronic Obstructive Pulmonary Disease
Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD
COPD Patients Have a Restricted Breathing Pattern That Persists with Increased Metabolic Demands.
Smaller Left Ventricle Size at Noncontrast CT Is Associated with Lower Mortality in COPDGene Participants.
Outcomes consequent to "early" COPD for interventional studies.
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease