Area of research
Molecular Biology · Neurology
Research interest
Research focused on Proteostasis and Protein aggregation, with related work in Heat shock protein, Chaperone (clinical), Hsp27. Notable publications include 'Invited review: Caseins and the casein micelle: Their biological functions, structures, and behavior in foods', 'Walking the tightrope: proteostasis and neurodegenerative disease', and 'The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity'.
Development of a targeted BioPROTAC degrader selective for misfolded SOD1
Competing chaperone pathways in α‐synuclein disaggregation and aggregation dynamics
A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis
Single-molecule observations of human small heat shock proteins in complex with aggregation-prone client proteins
Stress biology: Complexity and multifariousness in health and disease
The beauty and complexity of the small heat shock proteins: a report on the proceedings of the fourth workshop on small heat shock proteins
Real-time single-molecule observation of chaperone-assisted protein folding
The Monomeric α-Crystallin Domain of the Small Heat-shock Proteins αB-crystallin and Hsp27 Binds Amyloid Fibril Ends
Exploiting flow cytometry for the unbiased quantification of protein inclusions in <i>Caenorhabditis elegans</i>
Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health
DNAJB chaperones suppress destabilised protein aggregation via a region distinct from that used to inhibit amyloidogenesis
Illuminating amyloid fibrils: Fluorescence-based single-molecule approaches
De Novo Design, Synthesis, and Mechanistic Evaluation of Short Peptides That Mimic Heat Shock Protein 27 Activity
Regional Differences in Heat Shock Protein 25 Expression in Brain and Spinal Cord Astrocytes of Wild-Type and SOD1 G93A Mice
N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation
An α-Cyanostilbene Derivative for the Enhanced Detection and Imaging of Amyloid Fibril Aggregates
Single-molecule fluorescence-based approach reveals novel mechanistic insights into human small heat shock protein chaperone function
Native disulphide-linked dimers facilitate amyloid fibril formation by bovine milk αS2-casein
Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells
Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD
Small heat shock proteins: multifaceted proteins with important implications for life
High tolerance of repeated heatwaves in Australian native plants
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers
Proteostasis and the Regulation of Intra- and Extracellular Protein Aggregation by ATP-Independent Molecular Chaperones: Lens α-Crystallins and Milk Caseins
Using Single-Molecule Approaches to Understand the Molecular Mechanisms of Heat-Shock Protein Chaperone Function
Stress in native grasses under ecologically relevant heat waves
Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle tissue
The influence of the N-terminal region proximal to the core domain on the assembly and chaperone activity of αB-crystallin
The growing world of small heat shock proteins: from structure to functions