Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include MicroRNA in disease regulation, Pluripotent Stem Cells Research, CRISPR and Genetic Engineering, and Cancer-related molecular mechanisms research.
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function
KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition
Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation
Regionally distinct trophoblast regulate barrier function and invasion in the human placenta
Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells
The roles of microRNAs in mouse development
Single nuclei RNA-seq of mouse placental labyrinth development
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research
Epigenetic control of transcriptional regulation in pluripotency and early differentiation
GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency
Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells
FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity
miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation
miRNAs are critical for the regulation of RAG expression and secondary Ig rearrangement in peripheral B lymphocytes
Controlled induction of human pancreatic progenitors produces functional beta‐like cells <i>in vitro</i>
miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability
Biogenesis, delivery, and function of extracellular RNA
CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation
Let‐7 and miR‐125 cooperate to prime progenitors for astrogliogenesis
Regulation of Pluripotency by RNA Binding Proteins
Two miRNA Clusters Reveal Alternative Paths in Late-Stage Reprogramming
miR-19, miR-345, miR-519c-5p Serum Levels Predict Adverse Pathology in Prostate Cancer Patients Eligible for Active Surveillance
Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs
miR-294/miR-302 Promotes Proliferation, Suppresses G1-S Restriction Point, and Inhibits ESC Differentiation through Separable Mechanisms
microRNA Control of Mouse and Human Pluripotent Stem Cell Behavior
MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells
Epigenetics of cellular reprogramming
Sox1 marks an activated neural stem/progenitor cell in the hippocampus
Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex