Area of research
Molecular Biology · Plant Science
Research interest
Research focused on Heterochromatin and Chromatin, with related work in Promoter, FOXP3, Cohesin. Notable publications include 'Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome', 'Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing', and 'Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation'.
G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism
Evolution of T-cell fitness through AML progression: enhanced bispecific T-cell engager-mediated function of bone marrow T cells at remission compared to initial diagnosis and relapse
PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma
Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
DNA sequence-dependent formation of heterochromatin nanodomains
Specific effects of somatic GATA2 zinc finger mutations on erythroid differentiation
Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
HDAC2 Facilitates Pancreatic Cancer Metastasis
Evolving Exhaustion of T Cells during the Course of the Disease in AML Can be Abrogated By CD33 BiTE ® Construct Mediated Cytotoxicity
The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties
The <i>MDM2</i> inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma
Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer
DNA sequence-dependent formation of heterochromatin nanodomains
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
Loss of KDM6A confers drug resistance in acute myeloid leukemia
GATA2 Zinc Finger Mutations Influence Erythroid Differentiation and Chemotherapy Response
Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
Loss of KDM6A Confers Drug Resistance in Acute Myeloid Leukemia
A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination
A spherical harmonics intensity model for 3D segmentation and 3D shape analysis of heterochromatin foci
Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing
Specificity, propagation, and memory of pericentric heterochromatin
Heterochromatin-Mediated Gene Silencing Facilitates the Diversification of Olfactory Neurons
3D shape analysis of heterochromatin foci based on a 3D spherical harmonics intensity model
Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin