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Matthias Holdhoff

Seattle University · US
Area of research
Genetics · Cancer Research
Research interest
Research interests include Glioma Diagnosis and Treatment, Cancer, Hypoxia, and Metabolism, Brain Metastases and Treatment, and Radiopharmaceutical Chemistry and Applications.
h-index
42
citations
19,093
works
329
NIH funding
primary concept
Medicine
email

Recent publications

A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma
Science Translational Medicine 2025cited by 13position: middledoi
Vorasidenib in IDH1-mutant or IDH2-mutant low-grade glioma (INDIGO): secondary and exploratory endpoints from a randomised, double-blind, placebo-controlled, phase 3 trial
The Lancet Oncology 2025cited by 11position: middledoi
Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses
Science Translational Medicine 2025cited by 10position: middledoi
Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
Cancer Discovery 2025cited by 3position: middledoi
Preanalytical variables and analytes in liquid biopsy approach for brain tumors: A comprehensive review and recommendations from the RANO Group and the Brain Liquid Biopsy Consortium
Neuro-Oncology 2025cited by 3position: middledoi
Risk Factors, Indications, and Effectiveness of Cerebrospinal Fluid Diversion in Patients With High-Grade Glioma–Associated Hydrocephalus: A Systematic Review and Meta-Analysis
Neurosurgery 2025cited by 2position: middledoi
Value of Engagement in Digital Health Technology Research: Evidence Across 6 Unique Cohort Studies
Journal of Medical Internet Research 2024cited by 21position: middledoi
Molecular Testing for the World Health Organization Classification of Central Nervous System Tumors
JAMA Oncology 2024cited by 17position: middledoi
A Randomized, Double-blind, Phase 3 Study of Vorasidenib Versus Placebo in Patients with Mutant IDH1/2 Diffuse Glioma (INDIGO): Analysis of Health-related Quality of Life, Neurocognition and Seizures (PL5.003)
Neurology 2024cited by 6position: middledoi
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma
New England Journal of Medicine 2023cited by 690position: middledoi
NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022
Journal of the National Comprehensive Cancer Network 2023cited by 215position: middledoi
QOL-26. A RANDOMIZED, DOUBLE-BLIND PHASE 3 STUDY OF VORASIDENIB VS PLACEBO IN PATIENTS WITH MUTANT <i>IDH1/2</i>DIFFUSE GLIOMA (INDIGO): ANALYSIS OF HEALTH-RELATED QUALITY OF LIFE, NEUROCOGNITION AND SEIZURES
Neuro-Oncology 2023cited by 19position: middledoi
Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid
Cell Reports Medicine 2023cited by 18position: middledoi
LTBK-06. IMPACT OF VORASIDENIB TREATMENT ON MUTANT <i>IDH1</i> OR <i>IDH2</i> DIFFUSE GLIOMA TUMOR GROWTH RATE: RESULTS FROM THE RANDOMIZED, DOUBLE-BLIND, PHASE 3 INDIGO STUDY
Neuro-Oncology 2023cited by 18position: middledoi
A multi-institutional pilot clinical trial of spectroscopic MRI-guided radiation dose escalation for newly diagnosed glioblastoma
Neuro-Oncology Advances 2022cited by 41position: middledoi
Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies
British Journal of Cancer 2022cited by 29position: middledoi
Final Report on Clinical Outcomes and Tumor Recurrence Patterns of a Pilot Study Assessing Efficacy of Belinostat (PXD-101) with Chemoradiation for Newly Diagnosed Glioblastoma
Tomography 2022cited by 26position: middledoi
Central Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology
Journal of the National Comprehensive Cancer Network 2020cited by 556position: middledoi
Ivosidenib in Isocitrate Dehydrogenase 1<i>–</i>Mutated Advanced Glioma
Journal of Clinical Oncology 2020cited by 298position: middledoi
Optimizing eligibility criteria and clinical trial conduct to enhance clinical trial participation for primary brain tumor patients
Neuro-Oncology 2020cited by 40position: middledoi
MYD88 L265P mutation and CDKN2A loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas
Blood Advances 2019cited by 127position: middledoi
Incidence and clinicopathologic features of H3 K27M mutations in adults with radiographically-determined midline gliomas
Journal of Neuro-Oncology 2019cited by 127position: lastdoi
Evolving Treatments for Primary Central Nervous System Lymphoma
American Society of Clinical Oncology Educational Book 2019cited by 55position: middledoi
A multiprotein supercomplex controlling oncogenic signalling in lymphoma
Nature 2018cited by 401position: middledoi
Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy
Clinical Cancer Research 2018cited by 154position: middledoi
The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective
International Journal of Radiation Oncology*Biology*Physics 2018cited by 43position: middledoi
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Science 2017cited by 6,578position: middledoi
NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017
Journal of the National Comprehensive Cancer Network 2017cited by 230position: middledoi
Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas
Neuro-Oncology 2017cited by 55position: firstdoi
ACTR-46. AG-120, A FIRST-IN-class MUTANT IDH1 INHIBITOR IN PATIENTS WITH RECURRENT OR PROGRESSIVE IDH1 MUTANT GLIOMA: UPDATED RESULTS FROM THE PHASE 1 NON-ENHANCING GLIOMA POPULATION
Neuro-Oncology 2017cited by 34position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Patrick Y. Wen · Harvard University5 papers (2016–2024)Ingo K. Mellinghoff · University of Colorado Denver4 papers (2016–2024)Burt Nabors · Neurology, Inc4 papers (2016–2024)Hyunsuk Shim · Emory University3 papers (2018–2022)Gregory M. Coté · Sarcoma Oncology Center3 papers (2016–2020)Glenn J. Lesser · Virginia Commonwealth University3 papers (2016–2020)Stuart A. Grossman · Johns Hopkins University3 papers (2016–2020)Peter B. Barker · Kennedy Krieger Institute3 papers (2018–2022)Frank S. Lieberman · University of Pittsburgh3 papers (2016–2020)Richard L. Wahl · Siemens Healthcare (United States)3 papers (2016–2018)Benjamin M. Ellingson · Sylvester Comprehensive Cancer Center3 papers (2016–2020)Hui‐Kuo G. Shu · Emory University3 papers (2018–2022)Elizabeth A. Maher · Sorbonne Université3 papers (2016–2020)Timothy F. Cloughesy · UCLA Medical Center3 papers (2016–2020)Mehdi Touat · Université Paris 1 Panthéon-Sorbonne3 papers (2016–2020)Filip Jankú · The University of Texas MD Anderson Cancer Center3 papers (2016–2020)Serena Desideri · Johns Hopkins University2 papers (2016–2017)Macarena de la Fuente · University of Miami2 papers (2017–2022)Jon Weingart · Johns Hopkins University2 papers (2018–2025)Liewen Jiang · Daiichi Sankyo (United States)2 papers (2017–2020)