Area of research
Surgery · Genetics
Research interest
Research interests include Pancreatic function and diabetes, Diabetes and associated disorders, Diabetes Management and Research, and Metabolism, Diabetes, and Cancer.
Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes
IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes
The β-cell glucose toxicity hypothesis: Attractive but difficult to prove
Visualizing insulin vesicle neighborhoods in β cells by cryo–electron tomography
IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes
Type 2 diabetes as a protein misfolding disease
Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes
β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation
Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells
Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors
A Critical Analysis of the Clinical Use of Incretin-Based Therapies
β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?
β-Cell Mass and Turnover in Humans
Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the KrasG12D Mouse Model
Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling