Area of research
Physiology · Neurology
Research interest
Research focused on Acetylation and Dentate gyrus, with related work in Hippocampal formation, Neuroscience, Cell biology. Notable publications include 'A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models', 'Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration', and 'Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case–Control Study'.
Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation
Olfactory Threshold Test as a Quick Screening Tool for Cognitive Impairment: Analysis of Two Independent Cohorts
Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration
Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling
Alzheimer‐like tau accumulation in dentate gyrus mossy cells induces spatial cognitive deficits by disrupting multiple memory‐related signaling and inhibiting local neural circuit
P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models
Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy
T217-Phosphorylation Exacerbates Tau Pathologies and Tau-Induced Cognitive Impairment
Periphery Biomarkers for Objective Diagnosis of Cognitive Decline in Type 2 Diabetes Patients
Peripheral inflammation promotes brain tau transmission via disrupting blood–brain barrier
Tau acetylates and stabilizes β‐catenin thereby promoting cell survival
GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice
Tau Acetylation in Entorhinal Cortex Induces its Chronic Hippocampal Propagation and Cognitive Deficits in Mice
Co-Expression of Three Wild-Type 3R-Tau Isoforms Induces Memory Deficit via Oxidation-Related DNA Damage and Cell Death: A Promising Model for Tauopathies
Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease
TRPC1 Null Exacerbates Memory Deficit and Apoptosis Induced by Amyloid-β
Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity
GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory
Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice
Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case–Control Study