Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include DNA Repair Mechanisms, Mitochondrial Function and Pathology, Carcinogens and Genotoxicity Assessment, and Telomeres, Telomerase, and Senescence.
Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway
NAD <sup>+</sup> supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING
Signaling by cGAS–STING in Neurodegeneration, Neuroinflammation, and Aging
Ageing as a risk factor for neurodegenerative disease
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Lamin A/C promotes DNA base excision repair
NAD <sup>+</sup> supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice
Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms
NAD + in Aging: Molecular Mechanisms and Translational Implications
NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Nuclear DNA damage signalling to mitochondria in ageing
Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges
SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates
Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
Human RecQ Helicases in DNA Repair, Recombination, and Replication
A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation and mitochondrial dysfunction in the testis
Metformin improves healthspan and lifespan in mice
14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif