Area of research
Molecular Biology · Oncology
Research interest
Research focused on G protein-coupled receptor and Cell biology, with related work in Endocrinology, Osteoclast, RANKL. Notable publications include 'LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption', 'Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis', and 'PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis'.
The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer
Allogeneic CD19-targeted CAR-T therapy in refractory systemic lupus erythematosus achieved durable remission
Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer
Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis
PPIA dictates NRF2 stability to promote lung cancer progression
Engineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos
Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A2 receptors
Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos
Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos
Discovery of Pyridinone Derivatives as Potent, Selective, and Orally Bioavailable Adenosine A<sub>2A</sub> Receptor Antagonists for Cancer Immunotherapy
PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis
BCL6 confers KRAS-mutant non–small-cell lung cancer resistance to BET inhibitors
Impact of metabolic syndrome on sex hormones and reproductive function: a meta-analysis of 2923 cases and 14062 controls
The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation
Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin
Discovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages
Target Identification Among Known Drugs by Deep Learning from Heterogeneous Networks
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors
Heritable expansion of the genetic code in mouse and zebrafish
New functions and signaling mechanisms for the class of adhesion G protein–coupled receptors
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch
Aqp5 Is a New Transcriptional Target of Dot1a and a Regulator of Aqp2