Area of research
Immunology · Genetics
Research interest
Research interests include Immune Cell Function and Interaction, Diabetes and associated disorders, T-cell and B-cell Immunology, and Pancreatic function and diabetes.
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies
β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure
Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells
Clinical-Grade Multipotent Adult Progenitor Cells Durably Control Pathogenic T Cell Responses in Human Models of Transplantation and Autoimmunity
Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes
Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation
Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes
Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells
Peptide length determines the outcome of TCR/peptide-MHCI engagement
Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity