Area of research
Cardiology and Cardiovascular Medicine · Molecular Biology
Research interest
Research focused on Titin and Sarcomere, with related work in Ejection fraction, Cardiology, Nebulin. Notable publications include 'Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction', 'Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved...', and 'Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function'.
Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance
Effect of exercise on passive myocardial stiffness in mice with diastolic dysfunction
Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction
Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction
Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy
Phosphorylating Titin’s Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force
Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function