Area of research
Molecular Biology · Genetics
Research interest
Research interests include Estrogen and related hormone effects, Cancer-related gene regulation, Epigenetics and DNA Methylation, and Genomics and Chromatin Dynamics.
HP1 reshapes nucleosome core to promote phase separation of heterochromatin
Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
Structure of the full-length glucagon class B G-protein-coupled receptor
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand
Structure and Dynamics of the Liver Receptor Homolog 1–PGC1α Complex
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation
Full antagonism of the estrogen receptor without a prototypical ligand side chain
A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions