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Ernesto Freire

Johns Hopkins University · US
Area of research
Molecular Biology · Physical and Theoretical Chemistry
Research interest
Research interests include Protein Structure and Dynamics, thermodynamics and calorimetric analyses, Computational Drug Discovery Methods, and HIV Research and Treatment.
h-index
89
citations
24,102
works
295
NIH funding
primary concept
email

Recent publications

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Nature Medicine 2018cited by 312position: middledoi
Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529
Nature Chemical Biology 2017cited by 127position: middledoi
The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions
Nature Communications 2017cited by 115position: middledoi
Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus <i>ex Vivo</i> and Distribution <i>in Vivo</i>
ACS Nano 2015cited by 551position: middledoi
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
Nature Structural & Molecular Biology 2015cited by 368position: middledoi
CD4 mimetics sensitize HIV-1-infected cells to ADCC
Proceedings of the National Academy of Sciences 2015cited by 157position: middledoi
Characterization of Protein-Protein Interactions by Isothermal Titration Calorimetry
Methods in molecular biology 2015cited by 150position: lastdoi
Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env
Journal of Virology 2015cited by 131position: middledoi

Grants

Inhibition of Protein-Protein Interactions
NSF1157506$1,319,9982012–2018PIRePORTER
Cooperative Interactions in Proteins
NSF0641252$1,083,7782007–2012PIRePORTER
Cooperative Interactions in Proteins
NSF0131241$670,0002002–2007PIRePORTER
Cooperative Interactions In Proteins
NSF9816661$330,0001999–2002PIRePORTER
Physical Basis of Cooperativity in Protein Folding
NSF9118687$468,0001992–1996PIRePORTER
Acquisition of a Batch Microcalorimeter
NSF8219869$33,0001983–1984PIRePORTER

Frequent collaborators

Arne Schön · Johns Hopkins University5 papers (2015–2017)Marie Pancera · National Institute of Allergy and Infectious Diseases3 papers (2015–2017)Peter D. Kwong · National Institutes of Health3 papers (2015–2017)Joseph Sodroski · Harvard University3 papers (2015–2017)Andrés Finzi · McGill University2 papers (2015–2017)Aliaksandr Druz · National Institute of Allergy and Infectious Diseases2 papers (2015–2017)Sandeep Narpala · National Institute of Allergy and Infectious Diseases2 papers (2015–2017)Amos B. Smith · California University of Pennsylvania2 papers (2015–2017)Alon Herschhorn · University of Minnesota, Twin Cities2 papers (2017–2017)Gwo‐Yu Chuang · National Institutes of Health2 papers (2015–2017) · 2 papers (2015–2017)John R. Mascola · ApeX Therapeutics (United States)2 papers (2015–2017)Adrian B. McDermott · Sanofi (Mexico)2 papers (2015–2017)Joseph Van Galen · University of Rochester Medical Center1 papers (2015–2015) · 1 papers (2015–2015) · 1 papers (2015–2015)Guillaume B. E. Stewart-Jones · National Institute of Allergy and Infectious Diseases1 papers (2015–2015)Jason Gorman · National Institutes of Health1 papers (2015–2015)Walther Mothes · Yale University1 papers (2017–2017)Scott C. Blanchard · St. Jude Children's Research Hospital1 papers (2017–2017)