Area of research
Virology · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include HIV Research and Treatment, Monoclonal and Polyclonal Antibodies Research, Glycosylation and Glycoproteins Research, and HIV/AIDS drug development and treatment.
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron
Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants
Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth
Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth
Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature
Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
DeepSol: a deep learning framework for sequence-based protein solubility prediction
Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
Residue-Level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains
Application of asymmetric statistical potentials to antibody–protein docking