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Mark Ayers

Merck & Co., Inc., Rahway, NJ, USA (United States) · US
Area of research
Oncology · Cancer Research
Research interest
Research interests include Cancer Immunotherapy and Biomarkers, Colorectal Cancer Treatments and Studies, Cancer Genomics and Diagnostics, and Pancreatic and Hepatic Oncology Research.
h-index
40
citations
15,923
works
107
NIH funding
primary concept
Medicine
email

Recent publications

Associations of tissue tumor mutational burden and mutational status with clinical outcomes in KEYNOTE-042: pembrolizumab versus chemotherapy for advanced PD-L1-positive NSCLC
Annals of Oncology 2023cited by 69position: middledoi
Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma
Journal for ImmunoTherapy of Cancer 2022cited by 95position: middledoi
Biomarkers predictive of response to pembrolizumab in head and neck cancer
Cancer Medicine 2022cited by 45position: middledoi
Associations of Tissue Tumor Mutational Burden and Mutational Status With Clinical Outcomes With Pembrolizumab Plus Chemotherapy Versus Chemotherapy For Metastatic NSCLC
JTO Clinical and Research Reports 2022cited by 41position: middledoi
Transcriptomic Determinants of Response to Pembrolizumab Monotherapy across Solid Tumor Types
Clinical Cancer Research 2021cited by 73position: middledoi
Abstract CT084: Relationship between <i>STK11</i> and <i>KEAP1</i> mutational status and efficacy in KEYNOTE-042: pembrolizumab monotherapy versus platinum-based chemotherapy as first-line therapy for PD-L1-positive advanced NSCLC
Cancer Research 2020cited by 43position: middledoi
Pembrolizumab (pembro) plus platinum-based chemotherapy (chemo) for metastatic NSCLC: Tissue TMB (tTMB) and outcomes in KEYNOTE-021, 189, and 407
Annals of Oncology 2019cited by 104position: middledoi
Association between tissue TMB (tTMB) and clinical outcomes with pembrolizumab monotherapy (pembro) in PD-L1-positive advanced NSCLC in the KEYNOTE-010 and -042 trials
Annals of Oncology 2019cited by 100position: middledoi
OA04.06 Evaluation of TMB in KEYNOTE-189: Pembrolizumab Plus Chemotherapy vs Placebo Plus Chemotherapy for Nonsquamous NSCLC
Journal of Thoracic Oncology 2019cited by 93position: middledoi
LBA4 Association of KRAS mutational status with response to pembrolizumab monotherapy given as first-line therapy for PD-L1-positive advanced non-squamous NSCLC in Keynote-042
Annals of Oncology 2019cited by 92position: middledoi
KRAS mutational status and efficacy in KEYNOTE-189: Pembrolizumab (pembro) plus chemotherapy (chemo) vs placebo plus chemo as first-line therapy for metastatic non-squamous NSCLC
Annals of Oncology 2019cited by 82position: middledoi
OA04.05 KEYNOTE-021: TMB and Outcomes for Carboplatin and Pemetrexed With or Without Pembrolizumab for Nonsquamous NSCLC
Journal of Thoracic Oncology 2019cited by 64position: middledoi
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy
Science 2018cited by 2,309position: middledoi
T-Cell–Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028
Journal of Clinical Oncology 2018cited by 986position: middledoi
IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade
Journal of Clinical Investigation 2017cited by 3,821position: firstdoi
Genomic determinants of response to pembrolizumab in head and neck squamous cell carcinoma (HNSCC).
Journal of Clinical Oncology 2017cited by 56position: middledoi
Biomarkers and response to pembrolizumab (pembro) in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC).
Journal of Clinical Oncology 2016cited by 31position: middledoi
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
Nature Medicine 2015cited by 2,233position: middledoi
Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature.
Journal of Clinical Oncology 2015cited by 199position: middledoi
Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients.
Journal of Clinical Oncology 2015cited by 55position: middledoi
Relationship between immune gene signatures and clinical response to PD-1 blockade with pembrolizumab (MK-3475) in patients with advanced solid tumors
Journal for ImmunoTherapy of Cancer 2015cited by 41position: firstdoi
Correlation of gene expression signatures and clinical outcomes in patients with advanced gastric cancer treated with pembrolizumab (MK-3475).
Journal of Clinical Oncology 2015cited by 26position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Jared Lunceford · Merck & Co., Inc., Rahway, NJ, USA (United States)20 papers (2015–2023)Răzvan Cristescu · Merck & Co., Inc., Rahway, NJ, USA (United States)16 papers (2015–2023)Andrey Loboda · Merck & Co., Inc., Rahway, NJ, USA (United States)13 papers (2015–2023) · 13 papers (2015–2022)Julie Kobie · Merck & Co., Inc., Rahway, NJ, USA (United States)10 papers (2019–2023)Deepti Aurora-Garg · Merck & Co., Inc., Rahway, NJ, USA (United States)10 papers (2016–2023)Bilal Piperdi · Merck & Co., Inc., Rahway, NJ, USA (United States)9 papers (2019–2023)Jonathan D. Cheng · Southwestern Medical Center9 papers (2015–2022)M. Catherine Pietanza · Merck & Co., Inc., Rahway, NJ, USA (United States)8 papers (2019–2023)Tanguy Y. Seiwert · University Hospital and Clinics7 papers (2015–2022)Michael Nebozhyn · Merck & Co., Inc., Rahway, NJ, USA (United States)7 papers (2015–2021)Erin Murphy · New York University6 papers (2015–2018) · 5 papers (2015–2018)Shirish M. Gadgeel · The Barbara Ann Karmanos Cancer Institute5 papers (2019–2022)Ranee Mehra · The Ohio State University5 papers (2015–2022)Joseph P. Eder · Yale Cancer Center5 papers (2015–2022)Laura Q.M. Chow · The University of Texas at Austin5 papers (2015–2022)Antoni Ribas · UCLA Medical Center5 papers (2015–2021)Jared Weiss · University of North Carolina at Chapel Hill5 papers (2015–2022)Gregory M. Lubiniecki · Merck & Co., Inc., Rahway, NJ, USA (United States)4 papers (2019–2019)