Area of research
Radiology, Nuclear Medicine and Imaging · Virology
Research interest
Research interests include Monoclonal and Polyclonal Antibodies Research, HIV Research and Treatment, Glycosylation and Glycoproteins Research, and HIV/AIDS drug development and treatment.
Afucosylated broadly neutralizing antibodies enhance clearance of HIV-1 infected cells through cell-mediated killing
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
The Influence of Human IgG Subclass and Allotype on Complement Activation
Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike
Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection
Anti-HIV-1 Nanobody-IgG1 Constructs With Improved Neutralization Potency and the Ability to Mediate Fc Effector Functions
Immunoassay for quantification of antigen-specific IgG fucosylation
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages
Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike
Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
Cross-reactivity of mouse IgG subclasses to human Fc gamma receptors: Antibody deglycosylation only eliminates IgG2b binding
Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination
Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability
Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches
Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo
Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization
Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability
HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes
Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity
Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens
Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike