Area of research
Virology · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include HIV Research and Treatment, Monoclonal and Polyclonal Antibodies Research, HIV/AIDS drug development and treatment, and Immune Cell Function and Interaction.
Precise targeting of HIV broadly neutralizing antibody precursors in humans
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site
Immunization with germ line–targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
Antibody Responses to SARS-CoV-2 mRNA Vaccines Are Detectable in Saliva
Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens
Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure
Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo
Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization
cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vaccine candidate
Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes
A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype B <i>env</i> Gene
Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens
Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike
Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers
Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation
Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein