Area of research
Oncology · Genetics
Research interest
Research interests include BRCA gene mutations in cancer, HER2/EGFR in Cancer Research, Cancer Genomics and Diagnostics, and PI3K/AKT/mTOR signaling in cancer.
Generation of precision preclinical cancer models using regulated in vivo base editing
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation
PI3K activation promotes resistance to eribulin in HER2-negative breast cancer
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response
An <i>In Vivo Kras</i> Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis
PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition