Area of research
Oncology · Molecular Biology
Research interest
Research interests include Epigenetics and DNA Methylation, Immune Cell Function and Interaction, CAR-T cell therapy research, and Lymphoma Diagnosis and Treatment.
EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models
Biology as vulnerability in follicular lymphoma: genetics, epigenetics, and immunogenetics
EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility
Intravital three-photon microscopy allows visualization over the entire depth of mouse lymph nodes
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate
Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
Enhancer of zeste homolog 2 (EZH2) inhibitors
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma
Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region
Loss of BAP1 function leads to EZH2-dependent transformation
IL10 receptor is a novel therapeutic target in DLBCLs
Hematopoietic Stem Cell Origin of <i>BRAF</i> V600E Mutations in Hairy Cell Leukemia
Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance
EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation