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Charles A. Whittaker

Massachusetts Institute of Technology · US
Area of research
Pulmonary and Respiratory Medicine · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include Monoclonal and Polyclonal Antibodies Research, Lung Cancer Treatments and Mutations, Esophageal Cancer Research and Treatment, and Gastric Cancer Management and Outcomes.
h-index
49
citations
11,352
works
277
NIH funding
primary concept
email

Recent publications

Systematic perturbation of cultures of K. phaffii by carbon co-feeding show gene signatures associated with production of recombinant proteins
Microbial Cell Factories 2026cited by 0position: middledoi
Deletion of low-essentiality, secretion-associated genes enhances recombinant protein production in Komagataella phaffii
Microbial Cell Factories 2026cited by 0position: middledoi
Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses
Science Translational Medicine 2025cited by 10position: middledoi
Targeted degradation of CDK9 potently disrupts the MYC-regulated network
Cell chemical biology 2025cited by 9position: middledoi
Lung Cancer–Intrinsic SOX2 Expression Mediates Resistance to Checkpoint Blockade Therapy by Inducing Treg-Dependent CD8+ T-cell Exclusion
Cancer Immunology Research 2025cited by 8position: middledoi
Selection, Design, and Immunogenicity Studies of ASFV Antigens for Subunit mRNA Cocktail Vaccines with Specific Immune Response Profiles
ACS Infectious Diseases 2025cited by 8position: middledoi
Chikungunya: a decade of burden in the Americas
The Lancet Regional Health - Americas 2024cited by 128position: middledoi
Short-term post-fast refeeding enhances intestinal stemness via polyamines
Nature 2024cited by 51position: middledoi
Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses
Science Advances 2024cited by 31position: middledoi
CRISPR-Cas9 knockout screen informs efficient reduction of the Komagataella phaffii secretome
Microbial Cell Factories 2024cited by 4position: middledoi
Abstract B060: Unveiling resistance mechanisms to CAR T-cell therapy in pancreatic cancer through in vivo CRISPR/Cas9 knockout screening
Cancer Research 2024cited by 0position: middledoi
Abstract B039: Elucidating the tumor-driven mechanisms of resistance to immunotherapies in pancreatic cancer through in vivo CRISPR/Cas9 knockout screening
Cancer Immunology Research 2024cited by 0position: middledoi
Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
Cell 2023cited by 197position: middledoi
Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 to 19 Years in the US
JAMA Network Open 2023cited by 137position: middledoi
Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons
Neuron 2023cited by 49position: middledoi
Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening
Nature Communications 2023cited by 24position: middledoi
The environmental stress response regulates ribosome content in cell cycle-arrested S. cerevisiae
Frontiers in Cell and Developmental Biology 2023cited by 19position: middledoi
Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases
Cancer Research 2023cited by 19position: middledoi
A single-cell liver atlas of Plasmodium vivax infection
Cell Host & Microbe 2022cited by 96position: middledoi
Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells
bioRxiv (Cold Spring Harbor Laboratory) 2022cited by 3position: middledoi
Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice
Proceedings of the National Academy of Sciences 2021cited by 100position: middledoi
Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade
Cell Reports 2021cited by 42position: middledoi
Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus
Microbial Cell Factories 2021cited by 19position: middledoi
Identification of a long non-coding RNA regulator of liver carcinoma cell survival
Cell Death and Disease 2021cited by 5position: middledoi
The environmental stress response causes ribosome loss in aneuploid yeast cells
Proceedings of the National Academy of Sciences 2020cited by 38position: middledoi
Identifying Improved Sites for Heterologous Gene Integration Using ATAC-seq
ACS Synthetic Biology 2020cited by 24position: middledoi
Aneuploidy drives lethal progression in prostate cancer
Proceedings of the National Academy of Sciences 2019cited by 142position: middledoi
Host-Informed Expression of CRISPR Guide RNA for Genomic Engineering in <i>Komagataella phaffii</i>
ACS Synthetic Biology 2019cited by 75position: middledoi
Comparative genome‐scale analysis of <i>Pichia pastoris</i> variants informs selection of an optimal base strain
Biotechnology and Bioengineering 2019cited by 69position: middledoi
Expansion of the CD4+ effector T-cell repertoire characterizes peanut-allergic patients with heightened clinical sensitivity
Journal of Allergy and Clinical Immunology 2019cited by 60position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

J. Christopher Love · Massachusetts Institute of Technology9 papers (2016–2024)Neil C. Dalvie · Massachusetts Institute of Technology6 papers (2019–2026)Richard O. Hynes · Massachusetts Institute of Technology6 papers (2014–2023)Kerry R. Love · Massachusetts Institute of Technology6 papers (2016–2024)Joseph R. Brady · Massachusetts Institute of Technology4 papers (2019–2021)Angelika Amon · Massachusetts Institute of Technology4 papers (2014–2023)Steven A. Carr · Broad Institute3 papers (2014–2023)Daniel R. Goulet · Massachusetts Institute of Technology3 papers (2023–2024)Darrell J. Irvine · Scripps Research Institute3 papers (2021–2023)Michael T. Hemann · Massachusetts Institute of Technology3 papers (2023–2024)Duanduan Ma · Massachusetts Institute of Technology3 papers (2016–2019)Karl R. Clauser · Broad Institute3 papers (2014–2023)P Leclerc · Massachusetts Institute of Technology3 papers (2023–2024)Riley D. Hellinger · Massachusetts Institute of Technology3 papers (2023–2024)Alexandra Naba · University of Illinois Urbana-Champaign3 papers (2014–2017)Daniel G. Anderson · Massachusetts Institute of Technology2 papers (2017–2021)Niketa Nerurkar · Massachusetts Institute of Technology2 papers (2022–2024)Harini Narayanan · Massachusetts Institute of Technology2 papers (2026–2026)Sangeeta N. Bhatia · Broad Institute2 papers (2022–2024)Arzu Sandikci · Howard Hughes Medical Institute2 papers (2020–2023)