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Karl R. Clauser

Broad Institute ·
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Area of research
Spectroscopy · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include Advanced Proteomics Techniques and Applications, Monoclonal and Polyclonal Antibodies Research, Peptidase Inhibition and Analysis, and Mass Spectrometry Techniques and Applications.
h-index
77
citations
28,499
works
251
NIH funding
primary concept
Chemistry
email

Recent publications

Pancreatic cancer–restricted cryptic antigens are targets for T cell recognition
Science 2025cited by 54position: middledoi
HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
Cell 2025cited by 49position: middledoi
Precision proteogenomics reveals pan-cancer impact of germline variants
Cell 2025cited by 6position: middledoi
Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures
Cancer Cell 2025cited by 5position: middledoi
Pan-viral ORFs discovery using massively parallel ribosome profiling
Science 2025cited by 2position: middledoi
Pan-cancer proteogenomics characterization of tumor immunity
Cell 2024cited by 84position: middledoi
Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation
Nature Biotechnology 2024cited by 16position: middledoi
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
Cell 2023cited by 179position: middledoi
Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
Cancer Cell 2023cited by 100position: middledoi
Pan-cancer proteogenomics connects oncogenic drivers to functional states
Cell 2023cited by 99position: middledoi
Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues
Nature Communications 2023cited by 57position: middledoi
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery
Immunity 2023cited by 52position: middledoi
Deep learning integrates histopathology and proteogenomics at a pan-cancer level
Cell Reports Medicine 2023cited by 31position: middledoi
Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases
Cancer Research 2023cited by 19position: middledoi
The HLA-II immunopeptidome of SARS-CoV-2
Cell Reports 2023cited by 14position: middledoi
Cancer proteogenomics: current impact and future prospects
Nature reviews. Cancer 2022cited by 207position: middledoi
Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma
Journal of Clinical Investigation 2022cited by 29position: middledoi
Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma
Nature 2021cited by 537position: middledoi
A proteogenomic portrait of lung squamous cell carcinoma
Cell 2021cited by 384position: middledoi
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
Cancer Cell 2021cited by 376position: middledoi
Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer
Nature Biotechnology 2021cited by 295position: middledoi
Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics
Nature Communications 2021cited by 192position: middledoi
Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs
Cell 2021cited by 165position: middledoi
Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells
Nature Communications 2021cited by 90position: middledoi
Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples
Molecular & Cellular Proteomics 2021cited by 57position: middledoi
Author Correction: Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics
Nature Communications 2021cited by 6position: middledoi
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Cell 2020cited by 810position: middledoi
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
Cell 2020cited by 546position: middledoi
Proteogenomic Characterization of Endometrial Carcinoma
Cell 2020cited by 528position: middledoi
Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma
Cell Reports 2020cited by 154position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Steven A. Carr · Broad Institute22 papers (2014–2025)Richard O. Hynes · Massachusetts Institute of Technology9 papers (2014–2023)Alexandra Naba · University of Illinois Urbana-Champaign7 papers (2014–2019)D.R. Mani · Broad Institute6 papers (2017–2023)Jennifer G. Abelin · Massachusetts Institute of Technology6 papers (2017–2025)Susan Klaeger · Broad Institute6 papers (2019–2025)Nir Hacohen · Broad Institute6 papers (2017–2023)Karsten Krug · Frontier Aerospace Corporation (United States)4 papers (2017–2022)Siranush Sarkizova · Moderna Therapeutics (United States)4 papers (2017–2023)Chenxi Tian · Beijing Institute of Genomics3 papers (2019–2023)Shankha Satpathy · Broad Institute3 papers (2019–2023)Charles A. Whittaker · Massachusetts Institute of Technology3 papers (2014–2023)Catherine J. Wu · Dana-Farber/Harvard Cancer Center3 papers (2017–2021)Thomas Eisenhaure · Broad Institute3 papers (2017–2019)Bernhard Küster · German Cancer Research Center3 papers (2019–2021)Vamsi K. Mootha · Harvard University3 papers (2015–2017)Steffen Rickelt · Boehringer Ingelheim (Egypt)3 papers (2019–2023)Derin B. Keskin · Harvard University3 papers (2017–2021)Giacomo Oliveira · Harvard University2 papers (2019–2021)Niklas de Andrade Krätzig · TUM Klinikum2 papers (2021–2021)
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