Area of research
Molecular Biology · Oncology
Research interest
Research interests include Ubiquitin and proteasome pathways, Protein Degradation and Inhibitors, Peptidase Inhibition and Analysis, and Signaling Pathways in Disease.
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
The human zinc-binding cysteine proteome
Lactate regulates cell cycle by remodelling the anaphase promoting complex
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism
Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy
Discovery and Structure–Activity Relationship Study of ( <i>Z</i> )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors
Structural and functional consequences of the STAT5BN642H driver mutation
Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes
Transcription control by the ENL YEATS domain in acute leukaemia
Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands
MELK is not necessary for the proliferation of basal-like breast cancer cells
Data publication with the structural biology data grid supports live analysis
Phthalimide conjugation as a strategy for in vivo target protein degradation
A Strategy for Modulation of Enzymes in the Ubiquitin System
A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen
Two ZnF-UBP Domains in Isopeptidase T (USP5)