Area of research
Oncology · Molecular Biology
Research interest
Research interests include Cancer-related Molecular Pathways, Enzyme Structure and Function, RNA Research and Splicing, and Protein Kinase Regulation and GTPase Signaling.
Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket
Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes
Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)
A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition