Area of research
Molecular Biology · Neurology
Research interest
Research interests include Mitochondrial Function and Pathology, Amyotrophic Lateral Sclerosis Research, Cell death mechanisms and regulation, and Neurogenetic and Muscular Disorders Research.
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS
Misfolded SOD1 is not a primary component of sporadic ALS
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
Elevated PGC-1α Activity Sustains Mitochondrial Biogenesis and Muscle Function without Extending Survival in a Mouse Model of Inherited ALS