Area of research
Molecular Biology · Neurology
Research interest
Research interests include RNA Research and Splicing, Amyotrophic Lateral Sclerosis Research, RNA modifications and cancer, and Neurogenetic and Muscular Disorders Research.
Huntington’s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization
Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress
Large-scale tethered function assays identify factors that regulate mRNA stability and translation
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9
Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
Minor class splicing shapes the zebrafish transcriptome during development
Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration
Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis