Area of research
Molecular Biology · Oncology
Research interest
Research focused on Receptor and Amyloid precursor protein secretase, with related work in Pathogenesis, Tropomyosin receptor kinase B, Irritable bowel syndrome. Notable publications include 'Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome', 'Protease-activated receptors in health and disease', and 'Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2'.
Protease-activated receptors in health and disease
Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase
Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86
Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease
Mitochondrial dysfunction triggers the pathogenesis of Parkinson’s disease in neuronal C/EBPβ transgenic mice
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer’s disease
C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis
Cathepsin S Evokes PAR2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models
Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2
Lysosomal degradation products induce <i>Coxiella burnetii</i> virulence
TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion
Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes
N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease
Loss of <i>O</i> -Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators
N-Terminomics/TAILS Profiling of Macrophages after Chemical Inhibition of Legumain
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
Myoepithelial cell‐specific expression of stefin A as a suppressor of early breast cancer invasion