Area of research
Molecular Biology · Cancer Research
Research interest
Research focused on Ubiquitin and Deubiquitinating enzyme, with related work in Proteasome, Cell biology, Haploinsufficiency. Notable publications include 'Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease', 'Ubiquitination in the regulation of inflammatory cell death and cancer', and 'USP7 small-molecule inhibitors interfere with ubiquitin binding'.
The E3-ome gene-centric compendium reveals the human E3 ligase landscape
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
Targeting MCL‐1 and BCL‐2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non‐Hodgkin lymphoma: Results from preclinical models and a Phase Ib study
Targeted degradation via direct 26S proteasome recruitment
Targeted protein degradation: from small molecules to complex organelles—a Keystone Symposia report
Ubiquitination in the regulation of inflammatory cell death and cancer
Identifying transcriptional programs underlying cancer drug response with TraCe-seq
Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
Structurally-defined deubiquitinase inhibitors provide opportunities to investigate disease mechanisms
From Discovery to Bedside: Targeting the Ubiquitin System
Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
USP7 small-molecule inhibitors interfere with ubiquitin binding
Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights
Activity‐based probes for the multicatalytic proteasome
Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation
Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Toward understanding ubiquitin-modifying enzymes: from pharmacological targeting to proteomics