Patrick J. Hrdlicka

Molecular basis of UV lesion binding and repair inhibition by ETS-family transcription factors

DNA-targeting Invader probes: discovery, principles and applications

Efficient and specific DNA-targeting using single-stranded LNA/MOE mixmers and chimeric Invader:XenoRNA probes

An electrophoretic mobility shift assay with chemiluminescent readout to evaluate DNA-targeting oligonucleotide-based probes

Conformation matters: siRNAs with antisense strands with 5′-(<i>E</i>)-vinyl-phosphonate-α-<scp>l</scp>-LNA elicit stronger RNAi-mediated gene silencing than those with 5′-(<i>E</i>)-vinyl-phosphonate-LNA

Recognition of mixed-sequence double-stranded DNA regions using chimeric Invader/LNA probes

Metabolomic Analysis of Barley by Gas Chromatography/Mass Spectrometry

Serine-γPNA, Invader probes, and chimeras thereof: three probe chemistries that enable sequence-unrestricted recognition of double-stranded DNA

Factors Impacting Invader-Mediated Recognition of Double-Stranded DNA

CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma

Recognition of double-stranded DNA using LNA-modified toehold Invader probes

Nicked Invader probes: multistranded and sequence-unrestricted recognition of double-stranded DNA

Chimeric γPNA–Invader probes: using intercalator-functionalized oligonucleotides to enhance the DNA-targeting properties of γPNA

Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes

Head-to-head comparison of LNA, ^MPγPNA, INA and Invader probes targeting mixed-sequence double-stranded DNA

Recognition of mixed-sequence DNA targets using spermine-modified Invader probes

Synthesis and biophysical characterization of oligonucleotides modified with O2′-alkylated RNA monomers featuring substituted pyrene moieties

25 years and still going strong: 2′-<i>O</i>-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science

Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2′-triphenylene- and coronene-functionalized RNA monomers

Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes

Efficient Discrimination of Single Nucleotide Polymorphisms (SNPs) Using Oligonucleotides Modified with C5‐Pyrene‐Functionalized DNA and Flanking Locked Nucleic Acid (LNA) Monomers

Invader probes: harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications

Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles

Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent exciton coupling

Recognition of Double-Stranded DNA Using Energetically Activated Duplexes Modified with N2′-Pyrene-, Perylene-, or Coronene-Functionalized 2′-<i>N</i>-Methyl-2′-amino-DNA Monomers

Mixed-Sequence Recognition of Double-Stranded DNA Using Enzymatically Stable Phosphorothioate Invader Probes

Synthesis and characterization of oligodeoxyribonucleotides modified with 2′-thio-2′-deoxy-2′-S-(pyren-1-yl)methyluridine

Locked nucleic acid (LNA) induced effect on the hybridization and fluorescence properties of oligodeoxyribonucleotides modified with nucleobase-functionalized DNA monomers

Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)