Area of research
Molecular Biology · Organic Chemistry
Research interest
Research focused on Oligonucleotide and Locked nucleic acid, with related work in Nucleic acid, Combinatorial chemistry, Small interfering RNA. Notable publications include 'Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi...', 'Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)', and 'Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA'.
Conformation matters: siRNAs with antisense strands with 5′-(<i>E</i>)-vinyl-phosphonate-α-<scp>l</scp>-LNA elicit stronger RNAi-mediated gene silencing than those with 5′-(<i>E</i>)-vinyl-phosphonate-LNA
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease
Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent exciton coupling
Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)
C5-Amino acid functionalized LNA: positively poised for antisense applications
Synthesis, Hybridization Characteristics, and Fluorescence Properties of Oligonucleotides Modified with Nucleobase-Functionalized Locked Nucleic Acid Adenosine and Cytidine Monomers
C5-Alkynyl-Functionalized α-L-LNA: Synthesis, Thermal Denaturation Experiments and Enzymatic Stability
Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA
Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation—a case study using triplex-forming LNAs
Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines