Area of research
Molecular Biology
Research interest
Research interests include Pluripotent Stem Cells Research, CRISPR and Genetic Engineering, Renal and related cancers, and Epigenetics and DNA Methylation.
Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs
H3K36 methylation maintains cell identity by regulating opposing lineage programmes
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia
Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity
Reprogramming to recover youthful epigenetic information and restore vision
Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming
The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
Renewed proliferation in adult mouse cochlea and regeneration of hair cells
Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate
Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells
Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells
Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling
Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells
Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming
Sox2 Suppresses Gastric Tumorigenesis in Mice
A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2
Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells
Hallmarks of pluripotency
A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs
The histone chaperone CAF-1 safeguards somatic cell identity
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine
Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells
Failure to replicate the STAP cell phenomenon
Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma
Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming
Nanog Is Dispensable for the Generation of Induced Pluripotent Stem Cells
Histone Variant H2A.X Deposition Pattern Serves as a Functional Epigenetic Mark for Distinguishing the Developmental Potentials of iPSCs