Area of research
Molecular Biology · Physiology
Research interest
Research focused on Induced pluripotent stem cell and Neuroscience, with related work in Disease, CRISPR, Subtyping. Notable publications include 'Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9', 'A viral strategy for targeting and manipulating interneurons across vertebrate species', and 'Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1'.
Author Correction: Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Common genetic variation impacts stress response in the brain
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
Modeling gene x environment interactions in PTSD using glucocorticoid-induced transcriptomics in human neurons
Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction
Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells
Quality Control Guidelines for Clinical-Grade Human Induced Pluripotent Stem Cell Lines
Directed Differentiation of Human Pluripotent Stem Cells to Microglia
Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
A viral strategy for targeting and manipulating interneurons across vertebrate species
Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1
iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease