Area of research
Molecular Biology
Research interest
Research interests include Single-cell and spatial transcriptomics, CRISPR and Genetic Engineering, RNA and protein synthesis mechanisms, and Mitochondrial Function and Pathology.
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue
High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology
A platform for multimodal <i>in vivo</i> pooled genetic screens reveals regulators of liver function
Comparative landscape of genetic dependencies in human and chimpanzee stem cells
Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs
Multistep substrate binding and engagement by the AAA+ ClpXP protease